Why the study?
MR tissue phase mapping can encode voxel-wise myocardial motion velocity, but alterations in myocardial motion velocity in the functional ventricle of Fontan patients and their relationship to cardiac function needed quantification.
Does MR tissue phase mapping identify alterations in myocardial motion velocity and dyssynchrony in Fontan patients compared to normal controls?
Population
28 Fontan patients and 42 age- and sex-matched normal controls
Comparison
Fontan patients vs normal controls
Design
Prospective observational study
Key result
Fontan patients had significantly reduced peak longitudinal and radial myocardial motion velocities during systole and diastole compared to normal controls (all p<0.001).
Authors
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Reduced myocardial velocities in Fontan patients warrant cautious interpretation; hypothesis-generating for TPM in functional assessment.
Observational (n=70)
Does MR tissue phase mapping identify alterations in myocardial motion velocity and dyssynchrony in Fontan patients compared to normal controls?
p-value: p=<0.001
MR tissue phase mapping identifies significant regional myocardial motion abnormalities and dyssynchrony in Fontan patients, which correlate with reduced ejection fraction and cardiac output.
Lu et al. (2026) conducted an observational in Fontan circulation (n=70). Fontan circulation vs. Normal controls was evaluated on Peak longitudinal (Vz) and radial (Vr) myocardial motion velocities during systole and diastole (p=<0.001). Fontan patients had significantly reduced peak longitudinal and radial myocardial motion velocities during systole and diastole compared to normal controls (all p<0.001).
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