What does this research mean for the field?

There is a direct relationship between age-related changes in functional brain activity, as measured by multiscale entropy, and changes in structural connectivity over the adult lifespan. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to investigate how multiscale entropy relates to structural connectivity changes throughout the adult lifespan.

June 25, 20260 citationsOpen Access

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Structure function relationships of multiscale entropy over the adult lifespan

JSJack P. Solomon JNJosh Neudorf AMAnthony R. McIntosh

Key Points

This research aims to investigate how multiscale entropy relates to structural connectivity changes throughout the adult lifespan.
Direct comparison of multiscale entropy and structural connectivity measures over the adult lifespan.

Structured PICO

Population

Adults over the lifespan

Outcome

Changes in multiscale entropy (MSE) and structural connectivitysurrogate

This poster compares changes in multiscale entropy and structural connectivity over the adult lifespan.

Abstract

Aging is commonly associated with changes in brain structure and function. Multiscale entropy (MSE) has been used to characterize age related changes in functional brain activity, whereby aging is associated with a bias towards fine scale MSE. Likewise, the brain’s structure also appears to become less integrated and more segregated with age. This poster, presented at OHBM 2026, directly compares changes in MSE and structural connectivity over the adult lifespan.

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Structure function relationships of multiscale entropy over the adult lifespan

Key Points

Structured PICO

Abstract

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