Key result
68Ga-FAPI PET/CT detects persistent fibroblast activation in chronic ventricular aneurysms despite metabolic quiescence on 18F-FDG.
Case Report (n=1)
May identify active remodeling in chronic aneurysms missed by FDG; extends FAPI PET applications in post-MI remodeling research.
A 72-year-old man with a history of apical myocardial infarction 12 years earlier, complicated by a chronic left ventricular aneurysm, underwent 18 F-FDG PET/CT and 68 Ga-FAPI-46 PET/CT imaging. 18 F-FDG PET/CT, performed without cardiac preparation, showed a well-defined photopenic defect corresponding to the aneurysm, consistent with a nonviable transmural scar. In contrast, 68 Ga-FAPI PET/CT demonstrated intense uptake along the aneurysmal wall with a ring-like pattern at the basal border zone. This discordant pattern suggests persistent fibroblast activation despite metabolic quiescence, indicating that chronic ventricular aneurysms may remain biologically active rather than inert fibrotic sequelae.
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Querellou et al. (2026) conducted a case report in Chronic left ventricular aneurysm (n=1). 18F-FDG and 68Ga-FAPI-46 PET/CT imaging was evaluated. 68Ga-FAPI PET/CT showed intense uptake along the aneurysmal wall despite metabolic quiescence on 18F-FDG PET/CT, suggesting persistent fibroblast activation in chronic ventricular aneurysms.
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