January 1, 2008Circulation JournalOpen Access

Multifocal, Persistent Cardiac Uptake of 18-F-Fluoro-Deoxy-Glucose Detected by Positron Emission Tomography in Patients With Acute Myocardial Infarction

Q: What are the key findings of this study?

First acute myocardial infarction was associated with significantly higher multifocal cardiac FDG uptake compared to controls (1.28 vs 0.70, p<0.001), which persisted at 9 weeks follow-up.

Q: What is the clinical evidence from this study?

Study design: Case-Control. Population: Acute Myocardial Infarction (n=24). Intervention: First acute myocardial infarction vs. Controls (chronic stable angina or Printzmetal's variant angina). Primary outcome: Average FDG uptake (aFDGu) of 28 left ventricular wall segments (p=<0.001).

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Key result

First acute MI linked to ~83% higher multifocal cardiac FDG uptake persisting at 9 weeks.

P<0.001
n=24

Why the study?

Does cardiac [18-F]-fluoro-deoxy-glucose (FDG) uptake differ between patients with acute myocardial infarction and controls?

Population

12 fasting patients with first acute myocardial infarction single-vessel disease after successful primary…

Comparison

[18-F]-fluoro-deoxy-glucose positron emission… vs Controls (n=12)

Design

Case-control

Follow-up

9 weeks

Authors

CGCosmo Godino CMCristina Messa LGLuigi Gianolli

Discussion

Member takes

Overview

May signal remote post-AMI inflammation; case-control data leave open prognostic value and need for prospective trials.

Study Design

Type

Case-Control (n=24)

Multicenter

Structured PICO

Does cardiac [18-F]-fluoro-deoxy-glucose (FDG) uptake differ between patients with acute myocardial infarction and controls?

Population

24 nondiabetic patients (mean age 59, 17% female), comprising 12 with a first acute myocardial infarction and 12 controls, underwent PET imaging to assess cardiac inflammation up to 9 weeks.

Exposure

[18-F]-fluoro-deoxy-glucose (FDG) positron emission tomography/computed tomography (PET/CT) scan

Comparator

Controls (n=12)

Outcome

Cardiac [18-F]-fluoro-deoxy-glucose (FDG) uptake (average FDG uptake, aFDGu) in left ventricular wall segmentssurrogate

Main Result

Absolute Event Rate: 1.28% vs 0.7%

p-value: p=<0.001

Multifocal, non-infarct related cardiac FDG uptake occurs immediately after AMI and persists at 9 weeks, suggesting widespread myocardial inflammation.

Limitations

Cardiac FDG uptake was assessed semi-quantitatively
Plasma catecholamine levels were not reported
Very low incidence of episodes of recurrent coronary instability during follow-up prevents assessment of prognostic implications
Unexplained persistence of increased FDG uptake at follow-up despite reduced circulating IL-6 levels

Cite This Study

Godino et al. (2008) conducted a case-control in Acute Myocardial Infarction (n=24). First acute myocardial infarction vs. Controls (chronic stable angina or Printzmetal's variant angina) was evaluated on Average FDG uptake (aFDGu) of 28 left ventricular wall segments (p=<0.001). First acute myocardial infarction was associated with significantly higher multifocal cardiac FDG uptake compared to controls (1.28 vs 0.70, p<0.001), which persisted at 9 weeks follow-up.

synapsesocial.com/papers/6aa31581f7ce690ce548f891 https://doi.org/10.1253/circj.cj-08-0046

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January 1, 2008Circulation JournalOpen Access

Multifocal, Persistent Cardiac Uptake of 18-F-Fluoro-Deoxy-Glucose Detected by Positron Emission Tomography in Patients With Acute Myocardial Infarction

View Full Paper

Ask AI

Bookmark

Key result

First acute MI linked to ~83% higher multifocal cardiac FDG uptake persisting at 9 weeks.

P<0.001
n=24

Why the study?

Does cardiac [18-F]-fluoro-deoxy-glucose (FDG) uptake differ between patients with acute myocardial infarction and controls?

Population

12 fasting patients with first acute myocardial infarction single-vessel disease after successful primary…

Comparison

[18-F]-fluoro-deoxy-glucose positron emission… vs Controls (n=12)

Design

Case-control

Follow-up

9 weeks

Authors

CGCosmo Godino CMCristina Messa LGLuigi Gianolli

Discussion

Member takes

Overview

May signal remote post-AMI inflammation; case-control data leave open prognostic value and need for prospective trials.

Study Design

Type

Case-Control (n=24)

Multicenter

Structured PICO

Does cardiac [18-F]-fluoro-deoxy-glucose (FDG) uptake differ between patients with acute myocardial infarction and controls?

Population

24 nondiabetic patients (mean age 59, 17% female), comprising 12 with a first acute myocardial infarction and 12 controls, underwent PET imaging to assess cardiac inflammation up to 9 weeks.

Exposure

[18-F]-fluoro-deoxy-glucose (FDG) positron emission tomography/computed tomography (PET/CT) scan

Comparator

Controls (n=12)

Outcome

Cardiac [18-F]-fluoro-deoxy-glucose (FDG) uptake (average FDG uptake, aFDGu) in left ventricular wall segmentssurrogate

Main Result

Absolute Event Rate: 1.28% vs 0.7%

p-value: p=<0.001

Multifocal, non-infarct related cardiac FDG uptake occurs immediately after AMI and persists at 9 weeks, suggesting widespread myocardial inflammation.

Limitations

Cardiac FDG uptake was assessed semi-quantitatively
Plasma catecholamine levels were not reported
Very low incidence of episodes of recurrent coronary instability during follow-up prevents assessment of prognostic implications
Unexplained persistence of increased FDG uptake at follow-up despite reduced circulating IL-6 levels

Cite This Study

synapsesocial.com/papers/6aa31581f7ce690ce548f891 https://doi.org/10.1253/circj.cj-08-0046

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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