Key result
Glucose-loaded 18F-FDG-PET images showed significantly larger defect areas compared to 123I-BMIPP and 99mTc-TF SPECT images over 9 months of follow-up in patients with anterior acute myocardial infarction.
Why the study?
Does glucose-loaded 18F-FDG-PET show different serial changes in myocardial defect areas compared to 123I-BMIPP and 99mTc-TF SPECT in patients with anterior AMI after successful PCI?
Observational (n=7)
No
Does glucose-loaded 18F-FDG-PET show different serial changes in myocardial defect areas compared to 123I-BMIPP and 99mTc-TF SPECT in patients with anterior AMI after successful PCI?
Glucose-loaded 18F-FDG-PET shows persistently larger defect areas compared to 123I-BMIPP and 99mTc-TF SPECT up to 9 months after successful PCI for anterior AMI, suggesting prolonged impairment of glucose metabolism.
Answers are grounded in this paper and cite their sources.
Larger FDG-PET defects may signal prolonged metabolic impairment after anterior AMI; leaves open its added value over SPECT for post-PCI monitoring.
BACKGROUND: (18)F-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) is assumed to be the most useful method for evaluating the viability of the myocardium. However, there are few reports regarding serial changes in (18)F-FDG-PET images of acute myocardial infarction (AMI). We evaluated serial changes in glucose-loaded (18)F-FDG-PET, (123)I-β-methyl-p-iodophenyl-penta-decanoic acid (BMIPP) single-photon emission computed tomography (SPECT) and (99m)Tc-Tetrofosmin (TF) gated SPECT images in patients with AMI. METHODS AND RESULTS: We enrolled 7 consecutive patients with first anterior AMI who successfully underwent percutaneous coronary intervention (PCI). (18)F-FDG-PET images were obtained in the acute, subacute, chronic, mid-term and long-term phases. (123)I-BMIPP and (99m)Tc-TF SPECT images were obtained in the subacute, chronic, mid-term and long-term phases. We determined the total defect score (TDS) for each image. The TDS of the glucose-loaded (18)F-FDG-PET, (123)I-BMIPP and( 99m)Tc-TF SPECT images indicated significant serial decrease (P<0.001). Comparing these images, the TDS of the glucose-loaded (18)F-FDG-PET images was larger than that of the (123)I-BMIPP and (99m)Tc-TF SPECT images, and the TDS indicated (18)F-FDG-PET>(123)I-BMIPP>(99m)Tc-TF in all phases. CONCLUSIONS: The defect areas of glucose-loaded (18)F-FDG-PET images were significantly larger than those of (123)I-BMIPP and( 99m)Tc-TF SPECT images during 9 months follow-up of patients with successful PCI for anterior AMI. Additionally, the impairment of glucose metabolism was prolonged.
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Fukuoka et al. (2012) conducted an observational in Anterior acute myocardial infarction (n=7). Glucose-loaded 18F-FDG-PET imaging vs. 123I-BMIPP and 99mTc-TF SPECT imaging was evaluated on Total defect score (TDS) of myocardial scan images (p=<0.001). Glucose-loaded 18F-FDG-PET images showed significantly larger defect areas compared to 123I-BMIPP and 99mTc-TF SPECT images over 9 months of follow-up in patients with anterior acute myocardial infarction.
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