Key result
Diastolic dysfunction in diabetic patients is linked to ~61% higher risk of developing HF.
Why the study?
Studies have reported a high prevalence of preclinical diastolic dysfunction in patients with diabetes mellitus, but the associated outcomes required evaluation.
Does preclinical diastolic dysfunction increase the risk of developing heart failure in patients with diabetes mellitus?
Cohort (n=1,760)
No
Does preclinical diastolic dysfunction increase the risk of developing heart failure in patients with diabetes mellitus?
Hazard Ratio: 1.61 (95% CI 1.17–2.2)
Absolute Event Rate: 36.9% vs 16.8%
p-value: p=0.003
Preclinical diastolic dysfunction, identified by an elevated E/e' ratio, independently predicts the development of heart failure and increased mortality in patients with diabetes mellitus.
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Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“The key takeaway is that diabetes mellitus alone is an independent risk factor for the development of heart failure. Our hope is that this study provides a strong foundation for further investigations into diabetes and heart failure. There is still much to learn and study in terms of this association and how to best diagnose and treat this condition.”
Preclinical diastolic dysfunction may flag higher HF risk in diabetes; leaves open whether screening or intervention improves outcomes.
From et al. (2010) conducted a cohort in Diabetes Mellitus (n=1,760). Diastolic dysfunction (Doppler mitral E/e′ ratio >15) vs. No diastolic dysfunction was evaluated on Development of heart failure (HF) (HR 1.61, 95% CI 1.17-2.20, p=0.003). Diastolic dysfunction in diabetic patients was associated with a higher 5-year risk of developing heart failure compared to those without dysfunction (36.9% vs 16.8%; HR 1.61, 95% CI 1.17-2.20).
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