What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Pre-diabetes and diabetes (n=3840). Intervention: Pre-diabetes and diabetes vs. Normoglycaemia. Primary outcome: Abnormal diastolic variables (p=<0.001).

What does this research mean for the field?

Pre-diabetes and diabetes are associated with a similarly high prevalence of diastolic dysfunction, which is primarily driven by central adiposity, hypertension, and coronary atherosclerosis rather than isolated diabetic cardiomyopathy. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

To examine the prevalence of diastolic dysfunction and its associated risk factors in individuals with pre-diabetes and diabetes.

May 22, 2026Open HeartOpen Access

Diastolic dysfunction is equally common in pre-diabetes and diabetes and associated with concomitant cardiometabolic risk factors

Q: What are the key findings of this study?

Pre-diabetes and diabetes were associated with a similarly high prevalence of diastolic dysfunction (30% and 33% vs 21% in normoglycaemia, p<0.001), mainly driven by central adiposity and high CAC.

Q: What does this research mean for the field?

Pre-diabetes and diabetes are associated with a similarly high prevalence of diastolic dysfunction, which is primarily driven by central adiposity, hypertension, and coronary atherosclerosis rather than isolated diabetic cardiomyopathy. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

Q: What question did this study set out to answer?

To examine the prevalence of diastolic dysfunction and its associated risk factors in individuals with pre-diabetes and diabetes.

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Key result

Pre-diabetes and diabetes linked to ~50% greater diastolic dysfunction prevalence, driven by central adiposity and CAC.

P<0.001
n=3,840

Why the study?

To investigate the prevalence of diastolic dysfunction and associated risk factors in pre-diabetes and diabetes in the general population.

Is diastolic dysfunction more common in pre-diabetes and diabetes compared to normoglycaemia, and what are the associated risk factors?

Population

3840 men and women aged 50–64 years from the Swedish CArdioPulmonary bioImage Study

Comparison

Pre-diabetes and diabetes vs normoglycaemia

Design

Cross-sectional study

Authors

DKDavid KylhammarLinköping University LHL HultLinköping University PBPeter BlomstrandLinköping University

Discussion

Member takes

Implication

Screening for diastolic dysfunction may be considered in pre-diabetes alongside cardiometabolic risks; leaves open causal links and need for prospective trials.

Key Points

To examine the prevalence of diastolic dysfunction and its associated risk factors in individuals with pre-diabetes and diabetes.
Cross-sectional analysis of 3840 men and women aged 50–64 years from the Swedish CArdioPulmonary bioImage Study.
Diastolic function assessed by transthoracic echocardiography, with anthropometry, medical history, and CT coronary atherosclerosis recorded.
Comparison of diastolic function across glycaemic groups and correlation with various cardiovascular risk factors.
Diastolic dysfunction was present in 30% of pre-diabetic and 33% of diabetic participants, higher than 21% in normoglycaemic individuals (p<0.001).
Independent associations of diastolic dysfunction included waist circumference (OR 1.034, 95% CI 1.013 to 1.054) and high Coronary Artery Calcium Score (OR 2.897, 95% CI 1.373 to 6.113).
In individuals without coronary atherosclerosis or hypertension, systolic blood pressure was the sole independent predictor (OR 1.027, 95% CI 1.002 to 1.053).

Study Design

Type

Cross-Sectional (n=3,840)

Structured PICO

Is diastolic dysfunction more common in pre-diabetes and diabetes compared to normoglycaemia, and what are the associated risk factors?

Population

3840 men and women aged 50–64 years from the Swedish CArdioPulmonary bioImage Study

Intervention

Pre-diabetes and diabetes

Comparator

Normoglycaemia

Outcome

Prevalence of diastolic dysfunction assessed by transthoracic echocardiographysurrogate

Main Result

Absolute Event Rate: 33% vs 21%

p-value: p=<0.001

Diastolic dysfunction is equally common in pre-diabetes and diabetes, challenging the concept of isolated diabetic cardiomyopathy and emphasizing the role of central adiposity, hypertension, and coronary atherosclerosis.

Cite This Study

Kylhammar et al. (2026) conducted a cross-sectional in Pre-diabetes and diabetes (n=3,840). Pre-diabetes and diabetes vs. Normoglycaemia was evaluated on Abnormal diastolic variables (p=<0.001). Pre-diabetes and diabetes were associated with a similarly high prevalence of diastolic dysfunction (30% and 33% vs 21% in normoglycaemia, p<0.001), mainly driven by central adiposity and high CAC.

synapsesocial.com/papers/6a0ff33bd674f7c03778bd07 https://doi.org/10.1136/openhrt-2026-004052

Topics

Coronary artery disease

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Implication

Screening for diastolic dysfunction may be considered in pre-diabetes alongside cardiometabolic risks; leaves open causal links and need for prospective trials.

Diastolic dysfunction is equally common in pre-diabetes and diabetes and associated with concomitant cardiometabolic risk factors

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Diastolic dysfunction is equally common in pre-diabetes and diabetes and associated with concomitant cardiometabolic risk factors

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider