Key result
Among persons with type 1 diabetes, signs of diastolic dysfunction were present in 9% and systolic dysfunction in 8.2%, with age being the only significant risk factor for both.
Why the study?
Persons with type 1 diabetes have an increased risk of heart failure through unclear mechanisms, and it is unknown how established risk factors influence early heart failure development.
What is the prevalence of early signs of systolic and diastolic dysfunction in persons with type 1 diabetes, and what are the associated risk factors?
Cross-Sectional (n=287)
What is the prevalence of early signs of systolic and diastolic dysfunction in persons with type 1 diabetes, and what are the associated risk factors?
Persons with type 1 diabetes have a notable prevalence of early systolic (8.2%) and diastolic (9%) dysfunction, which is associated primarily with increasing age and prior myocardial infarction.
Supports early echocardiography in type 1 diabetes; extends risk stratification by confirming age and prior MI as dysfunction predictors.
Background: Persons with type 1 diabetes have a higher risk to develop heart failure than the general population, and the mechanism behind the increased risk is unclear. In epidemiological studies with hospitalisation for heart failure as endpoint HbA1c, body mass index and decreased kidney function are significant risk factors, but it is unclear how these risk factors influence the development of heart failure. Methods: In this study, we investigated early signs of systolic and diastolic dysfunction with transthoracic echocardiography. Statistical analysis on correlation of risk factors and early signs of diastolic and systolic dysfunction was made. Results: In this study population of 287 persons with type 1 diabetes, 160 were men and 127 were women with a mean age of 53.8 (SD 11.6) years and a mean diabetes duration of 36.2 (SD 13.5) years. There were 23 (8.2%) persons who fulfilled the definition of systolic dysfunction (ejection fraction <50% or regional wall motion abnormalities) and 24 persons (9%) the definition for diastolic dysfunction. When comparing the groups with either systolic or diastolic dysfunction to the rest of the population, the only significant risk factor was age in both groups and previous myocardial infarction in the systolic group. Conclusion: In our study population with type 1 diabetes, we found signs of diastolic dysfunction in 9% and systolic dysfunction in 8.2%. Compared with published data from the general population, this rate is somewhat higher in a younger population. Only age was a significant risk factor in the study.
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Vestberg et al. (2019) conducted a cross-sectional in Type 1 diabetes (n=287). Type 1 diabetes vs. General population (published data) was evaluated on Systolic dysfunction (ejection fraction <50% or regional wall motion abnormalities). Among persons with type 1 diabetes, signs of diastolic dysfunction were present in 9% and systolic dysfunction in 8.2%, with age being the only significant risk factor for both.
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