Key result
Each SD increment of plasma neopterin and KTR was associated with an increased risk of major coronary events (HR 1.28; 95% CI 1.10-1.48 and HR 1.28; 95% CI 1.12-1.48, respectively).
Why the study?
Do elevated systemic markers of IFN-γ activity (plasma neopterin and KTR) predict major coronary events and mortality in patients with stable coronary artery disease?
Population
2380 patients with stable angina pectoris and angiographically verified significant coronary artery disease…
Design
Cohort
Follow-up
median 56 months
Authors
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Neopterin and KTR may refine risk stratification in stable CAD; leaves open incremental value beyond conventional markers.
Cohort (n=2,380)
Do elevated systemic markers of IFN-γ activity (plasma neopterin and KTR) predict major coronary events and mortality in patients with stable coronary artery disease?
Hazard Ratio: 1.28 (95% CI 1.1–1.48)
Systemic markers of IFN-γ activity, specifically plasma neopterin and KTR, are significant predictors of long-term major coronary events and mortality in patients with stable coronary artery disease.
Pedersen et al. (2010) conducted a cohort in stable angina pectoris and angiographically verified significant coronary artery disease (n=2,380). Plasma neopterin and plasma kynurenine:tryptophan ratio (KTR) was evaluated on major coronary event (MCE) (HR 1.28, 95% CI 1.10 to 1.48). Each SD increment of plasma neopterin and KTR was associated with an increased risk of major coronary events (HR 1.28; 95% CI 1.10-1.48 and HR 1.28; 95% CI 1.12-1.48, respectively).
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