Key result
Abnormal CMR in suspected MINOCA is linked to up to ~50% MACE rates versus normal CMR.
Why the study?
Although cardiac magnetic resonance is considered a key diagnostic tool in MINOCA, limited data link the CMR diagnosis with clinical outcome.
Does cardiac magnetic resonance (CMR) imaging diagnosis predict major adverse cardiac events in patients with a working diagnosis of MINOCA?
Cohort (n=252)
No
Does cardiac magnetic resonance (CMR) imaging diagnosis predict major adverse cardiac events in patients with a working diagnosis of MINOCA?
p-value: p=<0.001
In patients with a working diagnosis of MINOCA, CMR imaging identifies the underlying cause in over half of cases and provides significant independent prognostic value, with a normal CMR portending a highly benign long-term prognosis.
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CMR diagnosis may stratify long-term MACE risk; leaves open prospective validation before guiding decisions.
Konst et al. (2023) conducted a cohort in Myocardial infarction with unobstructed coronary arteries (MINOCA) (n=252). Cardiac magnetic resonance (CMR) diagnosis (AMI, myocarditis, or NICM) vs. Normal CMR study was evaluated on Major adverse cardiac events (MACEs) (p=<0.001). In patients with suspected MINOCA, CMR diagnoses of AMI, myocarditis, and NICM were associated with higher 10-year MACE rates (47%, 24%, and 50%) compared to a normal CMR (3.5%; P<0.001).
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