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June 1, 1994Journal of VirologyOpen Access

VCAM-1 is a receptor for encephalomyocarditis virus on murine vascular endothelial cells

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Key result

VCAM-1 acts as a receptor for the D variant of encephalomyocarditis virus on murine vascular endothelial cells, and monoclonal antibodies to VCAM-1 inhibit infection and lysis.

Population

Murine vascular endothelial cells from the heart and CHO cells

Comparison

Monoclonal antibodies to VCAM-1; transfection… vs CHO cells transfected with the ELAM-1 gene

Design

Preclinical

Authors

SHSally A. HuberUniversity of Vermont

Discussion

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Implication

Hypothesis-generating for VCAM-1 blockade in murine viral myocarditis; leaves open translation to humans or clinical use.

Structured PICO

P
Population
Murine vascular endothelial cells from the heart and CHO cells
I
Intervention
Monoclonal antibodies to VCAM-1; transfection with VCAM-1 gene
C
Comparator
CHO cells transfected with the ELAM-1 gene
O
Outcome
Infection, lysis, and virus binding of EMC-D virussurrogate

Identifies VCAM-1 as a functional receptor for the EMC-D virus on murine vascular endothelial cells.

Cite This Study

Sally A. Huber (1994) studied Encephalomyocarditis virus infection. Monoclonal antibodies to VCAM-1 / VCAM-1 gene transfection vs. ELAM-1 gene transfection / control CHO cells was evaluated on Infection and lysis of endothelial cells / virus binding. VCAM-1 acts as a receptor for the D variant of encephalomyocarditis virus on murine vascular endothelial cells, and monoclonal antibodies to VCAM-1 inhibit infection and lysis.

synapsesocial.com/papers/6a3dc2a3c321b13bdd425c08https://doi.org/10.1128/jvi.68.6.3453-3458.1994
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immunomodulation of encephalomyocarditis virus-induced disease in A/J mice1991 · 19 citations
  2. 2Genetic Influences on the Immunologic Pathogenesis of Encephalomyocarditis (EMC) Virus-induced Diabetes Mellitus1985 · 14 citations
  3. 3Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells [published erratum appears in Blood 1990 Dec 1;76(11):2420]1990 · 533 citations
  4. 4Helper-Inducer T-Lymphocytes Mediate Diabetes in EMC-Infected BALB/c By J Mice1987 · 21 citations
  5. 5The Atomic Structure of Mengo Virus at 3.0 Å Resolution1987 · 357 citations