Key result
Novel chromosome 2 locus near NAT8 is linked to cardiovascular disease in people with HIV.
Observational (n=7,951)
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A novel genetic locus near NAT8 on chromosome 2 is associated with cardiovascular disease risk in people with HIV, highlighting unique genetic risk factors in this population.
People with HIV (PWH) experience a twofold higher risk of cardiovascular disease (CVD) despite effective antiretroviral therapy. A novel locus on chromosome 2 near NAT8 was associated with CVD in a multiancestry genome-wide association study of 7951 PWH from the Million Veteran Program. This gene is linked to renal function and oxidative stress, both relevant to CVD pathogenesis. Findings highlight the importance of genetic diversity in PWH to elucidate unique genetic risk factors for CVD.
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Titanji et al. (2026) conducted an observational in HIV and cardiovascular disease (n=7,951). Locus on chromosome 2 near NAT8 was evaluated on Cardiovascular disease. A novel locus on chromosome 2 near NAT8 was associated with cardiovascular disease in a multiancestry genome-wide association study of 7,951 people with HIV.
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