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June 26, 2026Respiratory ResearchOpen Access

H3K18 lactylation promotes allergic airway inflammation in asthma via a CSF1/CSF1R/MAPK autocrine axis

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Authors

MHMinxuan HuYCYuehua ChenHHH Huang

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Overview

Randomized trial demonstrates the role of histone lactylation in driving inflammation in asthma, suggesting a new therapeutic target.

Key Points

  • This research aims to investigate how histone lactylation influences inflammation in asthma via metabolic changes in airway epithelial cells.
  • Analyzed clinical specimens and single-cell RNA sequencing to map metabolic changes in asthma.
  • Assessed histone lactylation via western blotting and immunofluorescence.
  • Conducted ChIP-seq and RNA-seq to identify targets of H3K18 lactylation.
  • Glycolysis and histone lactylation (H3K18la) significantly increased in asthma airway epithelial cells.
  • Inhibition of glycolysis reduced inflammatory responses linked to histone lactylation.
  • H3K18la enhanced transcription at the CSF1R promoter, establishing a positive feedback loop in inflammation.

Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/6a3e16cd030ad1a9b30908bbhttps://doi.org/10.1186/s12931-026-03781-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1D21-23 The Role of Lactate Metabolism and Post-Translational Lactylation in Modulating Eosinophil Activation in Asthma2026
  2. 2Glycolytic reprogramming and cell-specific lactylation in asthma: an evidence-graded framework for testable metabolic-epigenetic profiles2026
  3. 3Histone Lactylation Enhances Th17 Cell Differentiation Through DPP4 to Promote Epithelial-Mesenchymal Transition in Asthma2026 · 2 citations
  4. 4C19-02 H3K18la-Mediated Ccl2/ccr2 Signaling Pathway Promotes Angiogenesis in Airway Injury Repair: Role and Mechanism2026
  5. 5Protective role of lactate in allergic airway inflammation: mitigation of inflammatory injury, epithelial barrier integrity restoration, and gut-lung axis involvement2026