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July 15, 2026Respiratory ResearchOpen Access

Protective role of lactate in allergic airway inflammation: mitigation of inflammatory injury, epithelial barrier integrity restoration, and gut-lung axis involvement

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Authors

MLMeilian LinJZJie ZhouYWYan Wang

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Overview

Randomized trial shows lactate mitigates airway inflammation in mice, suggesting new therapeutic avenues for asthma.

Key Points

  • To explore the protective role of lactate in allergic airway inflammation and its effects on epithelial barrier integrity and gut microbiota.
  • Established a mouse model of allergic airway inflammation using HDM.
  • Conducted a randomized double-blind trial with six female mice assigned to treatment groups.
  • Performed RNAseq analysis on lung tissues and 16S rRNA sequencing on fecal samples.
  • Lactate administration significantly reduced Th2 cytokines, inflammatory cell infiltration, and eosinophil extracellular traps (EETs) in mice (p<0.05).
  • Lactate inhibited pro-inflammatory pathways including MAPK and NF-κB, revealing its immunoregulatory effects.
  • Gut microbiota analysis showed increased abundance of beneficial bacteria like Lactobacillus and Bacteroides after lactate treatment.

Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/6a57239488b21df875480385https://doi.org/10.1186/s12931-026-03806-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1D21-23 The Role of Lactate Metabolism and Post-Translational Lactylation in Modulating Eosinophil Activation in Asthma2026
  2. 2H3K18 lactylation promotes allergic airway inflammation in asthma via a CSF1/CSF1R/MAPK autocrine axis2026
  3. 3Reducing Endogenous Lactate Production Ameliorates Ovalbumin-Induced Food Allergy via Regulating Lactylation and Microbial Homeostasis in Mice2025 · 5 citations
  4. 4Glycolytic reprogramming and cell-specific lactylation in asthma: an evidence-graded framework for testable metabolic-epigenetic profiles2026
  5. 5Lactate aggravates inflammation through the upregulation of ICAM-1 via GPR81-HSPA12B-mediated signaling in acute lung injury2024 · 2 citations