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This review explores the varying roles of Schlafen11 in brain tumors, emphasizing its dual prognostic potential.

The dual role of Schlafen11 in brain tumors: Jekyll and Hyde

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Review discusses Schlafen11's dual role as a biomarker in brain tumors, revealing conflicting prognostic implications.

This review explores the varying roles of Schlafen11 in brain tumors, emphasizing its dual prognostic potential.
Review of literature focusing on Schlafen11's roles in brain tumors
Analysis of cases demonstrating variable prognostic implications based on tumor type
Discussion of treatment responses related to SLFN11 expression levels
High SLFN11 expression is a positive prognostic marker in medulloblastomas and PCNSL.
In glioblastomas, high SLFN11 expression correlates with aggressive disease and risk of relapse after initial treatment.
Contradictory roles of SLFN11 highlight its significance in determining treatment outcomes.

Natsumeda et al. (2026) studied this question.

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