What question did this study set out to answer?

To characterize SLFN11 expression and determine its prognostic and predictive utility for response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer.

August 15, 2026BiomedicinesOpen Access

Integrated Bioinformatic and Experimental Analysis of SLFN11 Expression and Clinical Significance in Locally Advanced Rectal Cancer

View Full Paper

Ask AI

Bookmark

Authors

JJJelenko JelenkovicCenter for Health, Exercise and Sport Sciences MMMarko MiladinovCenter for Health, Exercise and Sport Sciences KEKatarina ErićUniversity of Belgrade

Discussion

Member takes

Implication

Translational study reveals post-chemoradiotherapy upregulation but limited prognostic value of SLFN11 in locally advanced rectal cancer, indicating its uncertain role as a predictive biomarker.

Key Points

To characterize SLFN11 expression and determine its prognostic and predictive utility for response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer.
Analyzed public multi-omic and transcriptomic datasets using UCSC Xena, GEPIA2, TNMplot, KMplot, ROC Plotter, and GEO databases.
Quantified SLFN11 expression via quantitative real-time PCR in paired tumor and adjacent non-tumor tissues collected before and after neoadjuvant chemoradiotherapy from 26 patients with locally advanced rectal cancer.
Public transcriptomic datasets showed lower SLFN11 expression levels in rectal tumor tissues relative to non-tumor tissues.
SLFN11 expression increased significantly following neoadjuvant chemoradiotherapy in both paired tumor and adjacent non-tumor tissues in the clinical cohort (N=26).
Bioinformatic databases and the clinical cohort demonstrated no statistically significant association between SLFN11 expression and survival outcomes or treatment response.

Cite This Study

Jelenkovic et al. (2026) studied this question.

synapsesocial.com/papers/6a8019a975c2e31742c85a86 https://doi.org/10.3390/biomedicines14081827

View Full Paper

Ask AI

Bookmark

Implication

Translational study reveals post-chemoradiotherapy upregulation but limited prognostic value of SLFN11 in locally advanced rectal cancer, indicating its uncertain role as a predictive biomarker.

Integrated Bioinformatic and Experimental Analysis of SLFN11 Expression and Clinical Significance in Locally Advanced Rectal Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Integrated Bioinformatic and Experimental Analysis of SLFN11 Expression and Clinical Significance in Locally Advanced Rectal Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider