Atorvastatin was as potent an anti-ischaemic agent as amlodipine, with >50% of patients becoming free of transient myocardial ischaemia in both monotherapy and combination groups.
RCT (n=311)
Double-blind
parallel-group
Yes
Does atorvastatin alone or in combination with amlodipine reduce transient myocardial ischaemia in patients with chronic stable angina compared to amlodipine alone?
Atorvastatin provides potent anti-ischemic effects comparable to amlodipine in patients with chronic stable angina, with no incremental anti-ischemic benefit from their combination.
AIMS: The DoUble-blind Atorvastatin AmLodipine (DUAAL) trial investigated whether atorvastatin decreases ischaemia by a vascular benefit, independent of low-density lipoprotein cholesterol lowering, in patients with coronary artery disease (CAD), both alone and in combination with the traditional anti-anginal therapy, amlodipine. METHODS AND RESULTS: Randomized, double-blind, parallel-group, multicountry trial (2 weeks run-in and 24 weeks active therapy) comparing three treatments: amlodipine, atorvastatin, and amlodipine + atorvastatin; in 311 patients (78% male; mean age 62 years) with stable angina (≥ 2 attacks/week), CAD history, ≥ 3 transient myocardial ischaemia (TMI) episodes, and/or ≥ 15 min ischaemia on 48 h ambulatory electrocardiographic (AECG) monitoring. Efficacy variables were change in TMI by AECG, exercise ischaemia, angina diary data, and inflammatory biomarkers at Week 26. There was a comparable, highly significant decrease in TMI with amlodipine and atorvastatin, but no additional benefit for the combination. More than 50% of patients became TMI-free in all three groups and this was accompanied by a comparable, marked reduction in angina and nitroglycerin consumption. High-sensitivity C-reactive protein fell by 40% in patients receiving atorvastatin but there was no change with amlodipine. Adverse events were comparable among groups. CONCLUSION: Atorvastatin was as potent an anti-ischaemic agent as amlodipine. Future studies of combination therapies will be instructive. CLINICAL TRIAL REGISTRATION INFORMATION: National clinical trial number: NCT00159718, protocol number A0531031 listed on http://clinicaltrials.gov/.
Deanfield et al. (Fri,) conducted a rct in chronic stable angina (n=311). atorvastatin vs. amlodipine and amlodipine + atorvastatin was evaluated on change in TMI by AECG, exercise ischaemia, angina diary data, and inflammatory biomarkers at Week 26. Atorvastatin was as potent an anti-ischaemic agent as amlodipine, with >50% of patients becoming free of transient myocardial ischaemia in both monotherapy and combination groups.