Why the study?
Does intensive lipid lowering with atorvastatin, with or without antioxidant vitamins, improve myocardial ischemia compared to moderate lipid lowering in patients with stable coronary artery disease?
Does intensive lipid lowering with atorvastatin, with or without antioxidant vitamins, improve myocardial ischemia compared to moderate lipid lowering in patients with stable coronary artery disease?
Intensive lipid lowering to LDL <80 mg/dL with atorvastatin, with or without antioxidant vitamins, does not provide additional benefit in reducing ambulatory ischemia or angina frequency compared to moderate lipid lowering to LDL <120 mg/dL in stable CAD.
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Moderate lipid lowering suffices to reduce ischemia in stable CAD; challenges need for intensification or vitamin addition in this setting.
Stone et al. (2005) studied this question.
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