Key result
Serial reassessment detects delayed troponin elevation at 48 hours leading to successful PCI.
Why the study?
ACS may present with initially nondiagnostic ECG findings and negative biomarkers, posing a diagnostic challenge and risk of delayed recognition.
Case Report (n=1)
Early reassuring ECG and troponin results do not rule out evolving ACS in patients with persistent symptoms, underscoring the need for continued observation and serial testing.
May warrant serial troponin checks beyond 24 h in high-suspicion ACS; case report leaves open optimal timing and generalizability.
Acute coronary syndrome (ACS) may present with initially nondiagnostic electrocardiographic findings and negative cardiac biomarkers, posing a diagnostic challenge and risk of delayed recognition. This is particularly relevant in cases involving coronary territories that are less well represented on standard ECG or in the setting of multivessel disease. We report the case of a 62-year-old man with hypertension who presented with typical chest pain of 2 hours’ duration. Initial evaluation showed sinus rhythm with left axis deviation, consistent with likely left anterior fascicular block, without acute ST-segment elevation. High-sensitivity troponin measurements at 0, 1, and 3 hours were negative. Despite low-risk scores, the patient was admitted for observation due to persistent symptoms. Forty-eight hours later, he developed recurrent chest pain with a marked rise in troponin T and new inferolateral T-wave inversions, confirming evolving myocardial injury. Coronary angiography revealed significant stenosis of the right coronary artery and left circumflex artery, and successful percutaneous coronary intervention was performed. The patient had an uneventful recovery. This case highlights the limitations of early ECG and troponin-based assessment in ACS and underscores the importance of clinical judgment and serial reassessment, particularly in patients with persistent symptoms despite initially reassuring investigations.
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Daas et al. (2026) conducted a case report in Acute coronary syndrome (n=1). Serial reassessment was evaluated on Delayed troponin elevation and evolving myocardial injury. Serial reassessment of a 62-year-old man with initially negative troponins revealed delayed troponin elevation at 48 hours, leading to successful percutaneous coronary intervention.
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