Key result
Change in the QRS axis after thrombolytic therapy did not correlate with infarct size overall (p=0.80), but correlated significantly in patients with isolated inferior MI (r=-0.52, p=0.049).
Why the study?
Does the change in QRS axis after thrombolytic therapy correlate with infarct size in patients with ST elevation acute myocardial infarction?
Observational
Does the change in QRS axis after thrombolytic therapy correlate with infarct size in patients with ST elevation acute myocardial infarction?
Effect estimate: r=-0.52 (in isolated inferior MI)
p-value: p=0.80 (overall), 0.049 (isolated inferior MI)
The change in QRS axis after thrombolytic therapy correlates with infarct size in patients with isolated inferior MI, offering a potential practical tool for prognostic assessment.
No correlation between post-thrombolysis QRS axis shift and infarct size in STEAMI; leaves open ECG utility for prognostic sizing and requires prospective validation.
OBJECTIVE: Electrocardiography (ECG) may be a practical guiding tool for prognostic infarct sizing in ST elevation acute myocardial infarction (STEAMI). In this study, we sought to find a relation between the infarct size and the change in the QRS axis after thrombolytic therapy. MATERIALS AND METHODS: Patients with STEAMI who received thrombolytic therapy were selected retrospectively. The mean QRS axes of two ECGs (before and 90 minutes after thrombolytic therapy) were calculated. Creatinine kinase MB (CKMB) was used as the marker of infarct size. RESULTS: We did not detect any correlation between infarct size and change in the QRS axis with respect to any myocardial infarction MI localizations (p=0.80). However, in the isolated inferior MI group, there was a good correlation between CKMB and change in the QRS axis (r=-0.52 p=0.049). CONCLUSION: The change in the QRS axis is rarely emphasized, providing a practical and promising tool for evaluating both the efficiency of the thrombolytic therapy and prognostic infarct sizing.
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Karakaş et al. (2012) conducted an observational in ST elevation acute myocardial infarction (STEAMI). Change in QRS axis was evaluated on Correlation between infarct size (CKMB) and change in the QRS axis (r=-0.52 (in isolated inferior MI), p=0.80 (overall), 0.049 (isolated inferior MI)). Change in the QRS axis after thrombolytic therapy did not correlate with infarct size overall (p=0.80), but correlated significantly in patients with isolated inferior MI (r=-0.52, p=0.049).
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