Key result
Impaired myocardial flow reserve was significantly associated with linear increases in end-systolic volume index (decrease of 3.7% per 10 ml/m2) and end-diastolic volume index in patients with non-ischemic systolic heart failure.
Why the study?
To investigate whether increasing end-systolic and end-diastolic volumes are associated with myocardial flow reserve measured by Rubidium-82 PET/CT in patients with non-ischemic systolic heart failure.
Is impaired myocardial flow reserve associated with increasing end-systolic and end-diastolic volumes in patients with non-ischemic systolic heart failure?
Population
151 patients with non-ischemic heart failure and initial LVEF ≤35%
Comparison
MFR across increasing indexed end-systolic and end-diastolic volumes
Design
Cross-sectional substudy of a randomized controlled multicenter trial
Authors
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Higher ESVI associated with lower MFR; leaves open whether remodeling impairs coronary flow reserve in prospective studies.
Cross-Sectional (n=151)
Yes
Is impaired myocardial flow reserve associated with increasing end-systolic and end-diastolic volumes in patients with non-ischemic systolic heart failure?
Effect estimate: estimate -3.7%/10 ml/m2 (95% CI -5.6 to -1.8)
p-value: p=< 0.001
In patients with non-ischemic systolic heart failure, impaired myocardial flow reserve measured by 82Rb-PET/CT is significantly associated with increased left ventricular volumes, suggesting microvascular dysfunction plays a role in disease progression.
Byrne et al. (2019) conducted a cross-sectional in Non-ischemic systolic heart failure (n=151). Increasing end-systolic and end-diastolic volume indices was evaluated on Myocardial flow reserve (MFR) (estimate -3.7%/10 ml/m2, 95% CI -5.6 to -1.8, p=< 0.001). Impaired myocardial flow reserve was significantly associated with linear increases in end-systolic volume index (decrease of 3.7% per 10 ml/m2) and end-diastolic volume index in patients with non-ischemic systolic heart failure.
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