Key result
Lower myocardial flow reserve is linked to worse GLS and LVEF in aortic stenosis.
Why the study?
Impaired myocardial flow reserve and stress myocardial blood flow on PET may identify adverse myocardial characteristics and injury in aortic stenosis, but their associations with LV remodeling and changes after AVR are unclear.
Are myocardial flow reserve and stress myocardial blood flow associated with adverse left ventricular remodeling and myocardial injury in patients with aortic stenosis?
Population
34 patients with predominantly moderate to severe AS and 34 matched controls without AS
Comparison
Patients with AS vs matched controls without AS
Design
Single-center prospective observational study
Follow-up
6 months after AVR for subset of 9 patients
Authors
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May link myocardial flow reserve to LV dysfunction severity in aortic stenosis; extends observational correlations but leaves open prognostic or therapeutic utility.
Observational (n=68)
No
Are myocardial flow reserve and stress myocardial blood flow associated with adverse left ventricular remodeling and myocardial injury in patients with aortic stenosis?
Effect estimate: β -0.31
p-value: p=.03
In patients with aortic stenosis, impaired myocardial flow reserve and stress myocardial blood flow on PET imaging are associated with adverse left ventricular remodeling and myocardial injury, and MFR improves following aortic valve replacement.
Zhou et al. (2021) conducted an observational in Aortic Stenosis (n=68). Myocardial flow reserve (MFR) and stress myocardial blood flow (MBF) vs. Matched controls without aortic stenosis was evaluated on Global longitudinal strain (GLS) (β -0.31, p=.03). In patients with aortic stenosis, myocardial flow reserve was independently associated with global longitudinal strain (β, -0.31; P=.03) and left ventricular ejection fraction (β, 0.41; P=.002).
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