Key result
Autonomic dysregulation in multiple sclerosis presents with various clinical symptoms that reduce quality of life, requiring early diagnosis and individualized interdisciplinary management.
This review highlights the importance of early diagnosis and multimodal management of autonomic dysfunction in patients with multiple sclerosis.
May warrant autonomic symptom screening in MS; leaves open targeted management strategies.
Multiple sclerosis (MS) is a chronic, progressive central neurological disease characterized by inflammation and demyelination. In patients with MS, dysregulation of the autonomic nervous system may present with various clinical symptoms including sweating abnormalities, urinary dysfunction, orthostatic dysregulation, gastrointestinal symptoms, and sexual dysfunction. These autonomic disturbances reduce the quality of life of affected patients and constitute a clinical challenge to the physician due to variability of clinical presentation and inconsistent data on diagnosis and treatment. Early diagnosis and initiation of individualized interdisciplinary and multimodal strategies is beneficial in the management of autonomic dysfunction in MS. This review summarizes the current literature on the most prevalent aspects of autonomic dysfunction in MS and provides reference to underlying pathophysiological mechanisms as well as means of diagnosis and treatment.
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Pintér et al. (2015) conducted a review in Multiple sclerosis. Autonomic dysfunction was evaluated. Autonomic dysregulation in multiple sclerosis presents with various clinical symptoms that reduce quality of life, requiring early diagnosis and individualized interdisciplinary management.
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