Key result
Autonomic nervous system testing revealed subjective symptoms of autonomic dysfunction in 45.45% and abnormal laboratory tests in 42.42% of patients with definite multiple sclerosis.
Cross-Sectional
Autonomic dysfunction is common and often subclinical in patients with multiple sclerosis, suggesting the need for combined testing for accurate evaluation.
Autonomic dysfunction appears common in MS; cross-sectional data leaves open whether routine combined testing improves outcomes.
OBJECTIVE: Patients with definite multiple sclerosis (MS) were tested for autonomic nervous system (ANS) dysfunction using clinical symptomatology criteria and non-invasive laboratory testing. Exactly 45.45% of patients exhibited subjective symptoms of autonomic dysfunction and 42.42% of patients had abnormal laboratory tests results. METHODS: The sympathetic ANS tests were abnormal in 30.3% of MS patients and the parasympathetic ANS tests were abnormal in 18.18% of MS patients. The most sensitive test for the presence of autonomic dysfunction was the sympathetic skin response. CONCLUSION: Autonomic dysfunction was often subclinical and we conclude that it is preferable to combine several tests for a more thorough and accurate evaluation of the ANS impairment in MS.
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Kodounis et al. (2005) conducted a cross-sectional in Multiple sclerosis. Autonomic nervous system testing was evaluated on Subjective symptoms of autonomic dysfunction. Autonomic nervous system testing revealed subjective symptoms of autonomic dysfunction in 45.45% and abnormal laboratory tests in 42.42% of patients with definite multiple sclerosis.
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