Key result
High CAVI scores linked to ~23% larger thoracic aortic volume and lower hemodynamic parameters.
Why the study?
CAVI measures arterial stiffness but does not assess blood flow or aortic shape, making the relationship between thoracic aortic volume, hemodynamic parameters, and CAVI unclear.
Does a high CAVI score correlate with altered thoracic aortic volume and hemodynamic parameters on 4D MRI in patients with suspected cardiac dysfunction?
Observational (n=171)
No
Does a high CAVI score correlate with altered thoracic aortic volume and hemodynamic parameters on 4D MRI in patients with suspected cardiac dysfunction?
High CAVI scores correlate with increased thoracic aortic volume and altered 4D MRI hemodynamic parameters, suggesting that aortic stiffness restricts luminal blood flow.
Larger TAV was associated with high CAVI; leaves open whether 4D MRI hemodynamics inform stiffness assessment.
The cardio-ankle vascular index (CAVI) is a noninvasive measure of arterial stiffness, but it does not assess blood flow or aortic shape. Four-dimensional (4D) magnetic resonance imaging (MRI) has emerged as a promising tool for evaluating vascular blood flow. This study investigated the correlation between thoracic aortic volume (TAV) and hemodynamic parameters using 4D MRI in patients with and without AA as defined by the CAVI score. This retrospective study involved 171 patients (77 with a low CAVI score and 94 with a high CAVI score) who underwent cardiac MRI with a 4D flow sequence. Thirty-two participants per group were propensity score matched. Hemodynamic parameters—including energy loss (EL), vorticity (Vort), and helicity (Hel)—were obtained. Patients in the high CAVI group had significantly larger TAV (101.9 ± 29.6 vs. 82.6 ± 29.4 cm3, P < 0.0001). The TAV was positively correlated with the CAVI score ( R = 0.4147, P < 0.0001). EL maximum/TAV ( P = 0.0005), Vort average/TAV ( P = 0.0025), and Hel absolute maximum/TAV ( P = 0.0007) were significantly lower in the high CAVI group. Several hemodynamic parameters, including Vort maximum/TAV ( R = −0.4082, P < 0.0001) and Hel right screw maximum/TAV ( R = −0.4211, P < 0.0001), were moderately negatively correlated with the CAVI score, suggesting that aortic stiffness restricts luminal blood flow, particularly during systole. Patients with high CAVI scores exhibited a larger TAV and lower voxel-based hemodynamic parameters than those with low CAVI scores. This method represents a novel approach for the noninvasive assessment of atherosclerosis.
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Koike et al. (2026) conducted an observational in Suspected cardiomyopathy or cardiac dysfunction (n=171). High CAVI score (≥ 8.0) vs. Low CAVI score (< 8.0) was evaluated on Thoracic aortic volume (TAV) (p=<0.0001). Patients with high CAVI scores exhibited a significantly larger thoracic aortic volume (101.9 vs 82.6 cm3) and lower voxel-based hemodynamic parameters than those with low CAVI scores.
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