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June 27, 2026PharmaciaOpen Access

Impact of antenatal steroid treatment on steroidogenic function and apoptotic remodeling in the suprarenal cortex of neonatal rats

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Authors

RSRasha A. SalmanHKHuda Rashid KamoonaHRHayder Ridha‐Salman

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Overview

Randomized trial evaluates suprarenal changes from antenatal steroid treatment in neonatal rats, indicating potential developmental impacts.

Key Points

  • This research assesses how prenatal dexamethasone and hydrocortisone impact the structure and function of neonatal suprarenal glands.
  • Sixty pregnant rats categorized by gestational timing and treatment into 12 subgroups.
  • Neonatal suprarenal glands analyzed for histological changes using H&E staining, StAR immunohistochemistry, and TUNEL assay.
  • Effects evaluated at postnatal days 1 and 15.
  • Dexamethasone reduced StAR expression significantly (0.2193 ± 0.0336 vs. 0.7662 ± 0.0692, p < 0.001).
  • Increased apoptosis observed in treated groups, particularly with late gestational dexamethasone exposure.
  • Suprarenal alterations were both time- and drug-dependent.

Cite This Study

Salman et al. (2026) studied this question.

synapsesocial.com/papers/6a3f67e2aea7db3c1953f1a6https://doi.org/10.3897/pharmacia.73.e182945
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