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June 27, 2026MedCommOpen Access

A Low Serum Calcium‐to‐Potassium Ratio Predicts Postpartum Venous Thromboembolism Risk: Mediation by Hemoglobin and D‐Dimer in a Multicenter Cohort

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Authors

QLQi LiGZGuofu ZhangXLX Li

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Overview

Randomized trial shows low serum calcium-to-potassium ratio increases postpartum VTE risk, suggesting intervention opportunities.

Key Points

  • This research explores the relationship between serum electrolyte levels and the risk of postpartum venous thromboembolism (VTE).
  • Included 25,792 pregnant women from Chinese multicenter cohort between January 2017 and December 2024.
  • Evaluated postpartum VTE occurrences within 6 weeks after delivery.
  • Applied mediation analyses to assess associations between serum electrolytes, hemoglobin, and D-dimer levels.
  • Low serum calcium-to-potassium ratio linked to increased postpartum VTE risk (overall association p=0.004).
  • Low serum calcium and high potassium levels were associated with postpartum VTE risk (p=0.032 and p=0.036, respectively).
  • Higher hemoglobin levels mediated 34.7% of the protective effect of a higher calcium-to-potassium ratio (p=0.036).

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6817aea7db3c1953f3edhttps://doi.org/10.1002/mco2.70843
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Predictive Value of <scp>d</scp> -Dimer Test for Venous Thromboembolism During Puerperium: A Prospective Cohort Study2020 · 12 citations
  2. 2The score settles it? maybe not: Navigating postpartum VTE prophylaxis2025
  3. 3Optimal ranges for maternal serum potassium and sodium: associations with hypertensive risks and major adverse pregnancy outcomes2025
  4. 4Assessment of Risk Factors and Risk Stratification for Venous Thromboembolism (VTE) in Pregnancy: A Study Conducted in A Tertiary Level Hospital2023
  5. 5Risk factors of pulmonary embolism in postpartum women2025