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June 27, 2026Cancer MedicineOpen Access

A Prognostic Risk Model Based on Immune Genes in Thyroid Cancer and Its Correlation With Tumor‐Associated Immune Cell Infiltration Abundance

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Authors

YZYufan ZhangSSShili SongXYXiaochen Yu

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Overview

Retrospective study investigates immune gene risk model in thyroid cancer, suggesting implications for patient prognosis.

Key Points

  • This research aims to develop a prognostic risk model for thyroid cancer based on immune gene expression and its relationship with immune cell infiltration.
  • Retrospective analysis of 117 thyroid cancer patients treated from May 2021 to December 2023.
  • COX regression model validated with ROC curves; immune cell subsets detected via flow cytometry.
  • External validation using TCGA thyroid cancer RNA-seq data (n = 512).
  • Lymph node metastasis (LNM), capsule invasion, and several immune genes are independent factors for poor prognosis (p < 0.05).
  • The prognostic model demonstrated an AUC of 0.925; significant variables included CDK1, B3GNT7, S100A9, and MMP12.
  • Correlation analysis revealed negative relationships between certain immune genes and B lymphocyte infiltration, while CD4+ and CD8+ T lymphocytes positively correlated with neutrophil and macrophage infiltration.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6817aea7db3c1953f4cehttps://doi.org/10.1002/cam4.72037
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Charting the immune terrain: a novel risk model for thyroid cancer prognosis2026
  2. 2Developing a Radiotherapy and Immune‐Related Genes‐Based Prognostic Model to Predict Prognosis and Immune Microenvironment in Thyroid Cancer2025 · 1 citations
  3. 3The Role of Immune Cells and Immune Related Genes in the Tumor Microenvironment of Thyroid Cancer Implications for Immunotherapy2024
  4. 4Construction of an immune-related gene prognostic model with experimental validation and analysis of immune cell infiltration in lung adenocarcinoma2024 · 1 citations
  5. 5Immune cell–related gene signatures for diagnostic and prognostic stratification in thyroid cancer using machine learning analysis2026 · 1 citations