What question did this study set out to answer?

To establish predictive cut-off values for lymphocyte subsets to improve the assessment of opportunistic infections (OIs) risk in people living with HIV/AIDS (PLWHA).

June 27, 2026BMC Infectious DiseasesOpen Access

Predictive value of peripheral lymphocyte subsets in relation to opportunistic infections in people living with HIV/AIDS

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To establish predictive cut-off values for lymphocyte subsets to improve the assessment of opportunistic infections (OIs) risk in people living with HIV/AIDS (PLWHA).
Peripheral blood samples were collected and lymphocyte subsets were assessed using flow cytometry from August 17, 2021, to April 19, 2023.
Correlation analysis identified lymphocyte subset indicators related to CD4 T-cell counts.
Receiver operating characteristic analysis determined cut-off values for predicting opportunistic infections.
CD4 + CD28 + T lymphocytes had an AUC of 0.819 with a cut-off of 129 cells/µl, indicating strong predictive value.
Other lymphocyte subsets showed AUCs > 0.800, with sensitivities over 90%.
Abnormal lymphocyte phenotypes significantly correlated with increased prevalence of opportunistic infections.

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Implication

Randomized trial identifies lymphocyte subset thresholds predicting opportunistic infections in HIV/AIDS, suggesting enhanced assessment strategies.

Cite This Study

Yuan et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6843aea7db3c1953f5a4 https://doi.org/10.1186/s12879-026-13866-7

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Implication

Randomized trial identifies lymphocyte subset thresholds predicting opportunistic infections in HIV/AIDS, suggesting enhanced assessment strategies.

Predictive value of peripheral lymphocyte subsets in relation to opportunistic infections in people living with HIV/AIDS

Key Points

Discussion

Implication

Cite This Study

Predictive value of peripheral lymphocyte subsets in relation to opportunistic infections in people living with HIV/AIDS

Key Points

Discussion

Implication

Cite This Study

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