What question did this study set out to answer?

To evaluate the correlation and diagnostic utility of serum high-density lipoprotein cholesterol (HDL-C) levels for predicting CD4+ T lymphocyte counts in antiretroviral therapy (ART)-naïve HIV patients.

January 1, 2025World Journal of AIDSOpen Access

Diagnostic Value of HDL-C for CD4+ T Lymphocyte Levels in ART-Naïve HIV Patients: A Retrospective Study

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To evaluate the correlation and diagnostic utility of serum high-density lipoprotein cholesterol (HDL-C) levels for predicting CD4+ T lymphocyte counts in antiretroviral therapy (ART)-naïve HIV patients.
Conducted a retrospective study collecting clinical and laboratory data from newly diagnosed, ART-naïve HIV patients.
Categorized patients into two groups based on CD4+ T lymphocyte thresholds and evaluated diagnostic performance using binary logistic regression and receiver operating characteristic (ROC) curve analyses.
Binary logistic regression revealed that HDL-C and CD8+ T lymphocyte counts were positively associated with CD4+ T lymphocyte levels, whereas log baseline viral load was negatively associated.
ROC curve analysis identified an optimal HDL-C cutoff of 1.015 mmol/L with an area under the curve (AUC) of 0.596.
ROC curves demonstrated superior diagnostic value for the CD4/CD8 ratio (cutoff 0.283, AUC 0.829) and CD8+ T lymphocyte count (cutoff 747.5/µL, AUC 0.800) relative to HDL-C.

Authors

ZLZhiwei LiuSun Yat-sen University HCHuifeng ChenHenan Normal University JLJinping LiangJiangsu University

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Implication

Retrospective study observes limited diagnostic accuracy of HDL-C for CD4+ T lymphocyte counts in ART-naïve HIV patients, indicating poor utility as an independent biomarker.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/6a9c46d815d4f46db465038e https://doi.org/10.4236/wja.2025.153005

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Implication

Retrospective study observes limited diagnostic accuracy of HDL-C for CD4+ T lymphocyte counts in ART-naïve HIV patients, indicating poor utility as an independent biomarker.

Diagnostic Value of HDL-C for CD4+ T Lymphocyte Levels in ART-Naïve HIV Patients: A Retrospective Study

Key Points

Discussion

Implication

Cite This Study

Diagnostic Value of HDL-C for CD4+ T Lymphocyte Levels in ART-Naïve HIV Patients: A Retrospective Study

Key Points

Discussion

Implication

Cite This Study

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