Key result
CD4 <200 in treatment-naïve HIV is linked to a ~62% rate of LV systolic dysfunction.
Why the study?
Previous studies suggested that treatment-naïve HIV-infected patients with very low CD4 cell counts (≤200/μl) are more likely to have cardiac complications, but the relationship with LV dimension and function needed evaluation.
Is there a relationship between CD4 cell count and left ventricular dimension and function in treatment-naïve HIV-infected patients?
Observational (n=150)
Is there a relationship between CD4 cell count and left ventricular dimension and function in treatment-naïve HIV-infected patients?
Absolute Event Rate: 61.9% vs 12.1%
p-value: p=0.001
Treatment-naïve HIV patients have larger LV dimensions and higher rates of systolic and diastolic dysfunction compared to healthy controls, with systolic dysfunction correlating with lower CD4 counts.
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May support CD4-guided echocardiography in treatment-naïve HIV; hypothesis-generating for prospective validation of risk stratification.
Adebola et al. (2019) conducted an observational in HIV infection (n=150). CD4 cell count <200/μl vs. CD4 cell count >200/μl was evaluated on Left ventricular systolic dysfunction (p=0.001). In treatment-naïve HIV patients, CD4 count <200/μl was associated with higher rates of LV systolic dysfunction (61.9% vs 12.1%) and positively correlated with LV systolic function (r=0.384, P=0.001).
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