Key result
HIV infection linked to altered GLS versus healthy volunteers, correlating with CD4 T-cell levels.
Why the study?
There is limited data on cardiac functions in HIV-infected patients and the ability of global longitudinal strain to detect subclinical myocardial dysfunction earlier than conventional echocardiography.
Does HIV infection associate with subclinical left ventricular systolic dysfunction measured by global longitudinal strain compared to healthy volunteers?
Case-Control (n=113)
Does HIV infection associate with subclinical left ventricular systolic dysfunction measured by global longitudinal strain compared to healthy volunteers?
p-value: p=0.003
Global longitudinal strain can detect subtle left ventricular systolic dysfunction in asymptomatic HIV-infected patients, which correlates with reduced CD4 T-cell counts.
GLS may identify subclinical LV dysfunction in asymptomatic HIV; leaves open prognostic value and management implications.
BACKGROUND: Although left ventricular systolic dysfunction (LVSD) is a major cause of morbidity in human immunodeficiency virus (HIV)-infected patients, there is limited data on cardiac functions of these patients. Compared to the conventional echocardiography, the global longitudinal strain (GLS) can detect subclinical myocardial dysfunction at an earlier stage. OBJECTIVES: In our study, we aimed to evaluate left ventricular systolic functions using the GLS in HIV-infected patients and to investigate the effect of cluster of differentiation 4 T-cell values on LVSD. METHODS: This prospective, case-control study included a total of 65 HIV-infected patients and 48 healthy volunteers. Conventional and strain echocardiography were performed on all participants. In HIV-infected patients, CD4 T-cell counts and HIV-ribonucleic acid (HIV-RNA) values were measured. RESULTS: in the HIV-infected patients and median duration of living with HIV was 16.25 (range: 2 to 120) months. Baseline characteristics and left ventricular ejection fraction values were similar in both groups. However, there was a significant difference in the low-density lipoprotein cholesterol, triglycerides, interventricular septum, left ventricular posterior wall, and GLS between the groups (p = 0.013, p = 0.005, 0.041, p = 0.013, and p = 0.003, respectively). There was a positive correlation between GLS and CD4 levels (r = 0.463, p < 0.001). CONCLUSIONS: Our study results suggest that reduced CD4 T-cell counts in HIV-infected patients may cause myocardial dysfunction and GLS can be useful to show subtle LVSD asymptomatic cases.
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Çetin et al. (2018) conducted a case-control in Human Immunodeficiency Virus (HIV) (n=113). HIV infection vs. Healthy volunteers was evaluated on Global longitudinal strain (GLS) (p=0.003). HIV infection was associated with a significant difference in global longitudinal strain compared to healthy volunteers (p=0.003), which positively correlated with CD4 T-cell levels (r=0.463, p<0.001).
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