What question did this study set out to answer?

This research aims to enhance treatment strategies for secondary central nervous system lymphoma by analyzing real-world outcomes.

Response‐adapted consolidation and salvage strategies in secondary central nervous system lymphoma: Insights from a multicentre cohort

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Multicentre cohort study identifies key treatments for outcomes in secondary CNS lymphoma, suggesting optimized strategies.

This research aims to enhance treatment strategies for secondary central nervous system lymphoma by analyzing real-world outcomes.
Conducted a multicentre retrospective cohort study with 105 adult patients diagnosed with SCNSL from 2016 to 2024.
Captured detailed treatment sequencing, response dynamics, and outcome data across four German academic centres.
Analyzed the effects of HDT-AHSCT and CAR T therapy on patient survival outcomes.
Median progression-free survival was 7.62 months (95% CI 5.34–9.90).
Median overall survival was 16.62 months (95% CI 5.91–27.33).
CAR T therapy showed significantly improved outcomes versus non-transplant salvage therapy (OS HR 0.28, p=0.039; PFS HR 0.37, p=0.025).

Eigendorff et al. (2026) studied this question.

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