What question did this study set out to answer?

This research aims to assess the impact of different treatment regimens on the survival of patients with primary central nervous system lymphoma.

February 9, 2026CancersOpen Access

Clinical Characteristics and Prognosis of Primary Central Nervous System Lymphoma: A Retrospective Analysis

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Authors

SZShupeng ZhongPeking University LZLinjun ZhaoPeking University JCJin ChaiPeking University

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Implication

Retrospective analysis evaluates treatment effects on long-term survival in immunocompetent patients with PCNSL, suggesting improved outcomes with specific therapies.

Key Points

This research aims to assess the impact of different treatment regimens on the survival of patients with primary central nervous system lymphoma.
Retrospective analysis of 140 immunocompetent patients with diffuse large B-cell PCNSL treated at two centers.
Treatment efficacy evaluated through baseline characteristics and therapeutic regimens.
Progression-free survival (PFS) and overall survival (OS) estimated using Kaplan–Meier method.
Prognostic factors identified through multivariate Cox proportional hazards regression.
Median follow-up was 5.3 years; 2-year PFS rates were 50.4% and 5-year rates were 34.1%.
Induction therapy with R-MT showed 2-year PFS rates of 57.7%, while MT alone had 39.7%.
75% of patients achieved remission post-induction, with 55% receiving consolidation therapy, primarily ASCT.
Patients undergoing ASCT had superior survival compared to those who did not receive it.

Cite This Study

Zhong et al. (2026) studied this question.

synapsesocial.com/papers/698979c8f0ec2af6756e7bba https://doi.org/10.3390/cancers18030541

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Implication

Retrospective analysis evaluates treatment effects on long-term survival in immunocompetent patients with PCNSL, suggesting improved outcomes with specific therapies.

Clinical Characteristics and Prognosis of Primary Central Nervous System Lymphoma: A Retrospective Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Clinical Characteristics and Prognosis of Primary Central Nervous System Lymphoma: A Retrospective Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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