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October 1, 2025Turkish Journal of Clinics and LaboratoryOpen Access

When location meets biology: combined risk patterns drive outcomes in primary central nervous system lymphoma

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Authors

EHEmre HafızoğluState HospitalSSSerhat SekmekBilkent UniversityDBDoğan BayramMemorial Ankara Hospital

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Overview

Retrospective analysis reveals prognostic factors influencing overall survival in PCNSL patients, suggesting risk-adapted strategies.

Key Points

  • Poor outcomes were observed in patients with deep brain involvement and germinal center B-cell subtype.
  • Overlapping high-risk features limited multivariate analysis, indicating complexity in determining prognostic factors.
  • The median overall survival was 13.6 months, emphasizing the aggressive nature of primary central nervous system lymphoma.
  • This analysis contributes real-world data from immunocompetent patients, underlining the need for tailored treatment approaches.

Cite This Study

Hafızoğlu et al. (2025) studied this question.

synapsesocial.com/papers/68dd91d5fe798ba2fc498fe4https://doi.org/10.18663/tjcl.1761637
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of treatment regimens and prognostic factors in primary central nervous system lymphomas2025 · 1 citations
  2. 2Clinical characteristics and prognosis of primary central nervous system lymphoma in China: a single-center retrospective analysis of 325 patients.2025
  3. 3Clinical Characteristics and Prognosis of Primary Central Nervous System Lymphoma: A Retrospective Analysis2026 · 2 citations
  4. 4PROGNOSTIC FACTORS INFLUENCING TREATMENT RESPONSE IN PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA2025
  5. 5Outcomes and relapse patterns in primary central nervous system lymphoma: Longitudinal analysis of 559 patients diagnosed from 1983 to 20202024 · 6 citations