Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Patient characteristics, treatment patterns, and outcomes in primary CNS lymphoma of T-cell origin: A multi-institution retrospective analysis

View Full Paper
Ask AI
Bookmark
Share

Authors

OEOmar ElghawyNSNishwant SwamiFEFelix Ehret

Discussion

Loading...

Member takes

Overview

Retrospective analysis shows treatment regimens influence progression-free survival in primary CNS T-cell lymphoma patients, suggesting the need for standard protocols.

Key Points

  • To identify clinicopathologic factors and treatment patterns associated with outcomes in primary CNS T-cell lymphoma.
  • Multicenter retrospective study across 15 North American institutions
  • Included adults with biopsy-confirmed primary CNS T-cell lymphoma
  • Analyzed baseline characteristics using statistical tests like t-tests and chi-square tests
  • Median progression-free survival was 8.2 months
  • Notable mutations were found in TP53 and DNMT3A in some patients
  • Response to first-line therapy was seen in 63% of patients

Cite This Study

Elghawy et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d8e4https://doi.org/10.1182/blood-2025-893
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of treatment regimens and prognostic factors in primary central nervous system lymphomas2025 · 1 citations
  2. 2Real-world treatment patterns and survival outcomes in primary CNS lymphoma: Analysis of the national cancer database2025 · 1 citations
  3. 3When location meets biology: combined risk patterns drive outcomes in primary central nervous system lymphoma2025 · 1 citations
  4. 4PROGNOSTIC FACTORS INFLUENCING TREATMENT RESPONSE IN PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA2025
  5. 5Reduced Intensity Therapy for Primary Central Nervous System Post-Transplant Lymphoproliferative Disorders is Associated with Preserved Survival Outcomes: A Twenty-Year Single-Institutional Experience2025