What question did this study set out to answer?

The study aims to investigate the effects of arsenic exposure on multiple organs in female mice during pre-pregnancy, gestation, and lactation.

June 27, 2026Journal of Applied Toxicology

Effects of Environmental Arsenic Exposure on the Morphology of Multiple Organs in Female Mice During Pre‐Pregnancy, Gestation, and Lactation

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Authors

YXYing XingShanxi Agricultural University SLShu LiuShanxi Agricultural University WLWenchao LiuShanxi Medical University

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Implication

Randomized trial investigates arsenic exposure effects on organ morphology in female mice, indicating potential vulnerability during gestation and lactation.

Key Points

The study aims to investigate the effects of arsenic exposure on multiple organs in female mice during pre-pregnancy, gestation, and lactation.
Established exposure models with 0.02, 0.1, and 0.5 mg/L arsenic during three reproductive stages in mice.
Evaluated fertility, blood parameters, and organ pathological changes.
Assessed DNA damage (γH2AX) and apoptosis (TUNEL) in liver and kidney during gestation and lactation.
Exposure to 0.5 mg/L arsenic during gestation reduced red blood cells, hemoglobins, and platelets.
Increased hepatic lipid levels were noted with 0.1 mg/L arsenic during gestation; 0.1 mg/L during lactation caused glomerular atrophy and hepatocyte vacuolization.
Elevated γH2AX levels were observed in kidneys at doses of 0.1 and 0.5 mg/L during gestation and lactation, indicating toxicity, while TUNEL showed no significant changes in apoptosis.

Cite This Study

Xing et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6871aea7db3c1953f78d https://doi.org/10.1002/jat.70305

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Implication

Randomized trial investigates arsenic exposure effects on organ morphology in female mice, indicating potential vulnerability during gestation and lactation.

Effects of Environmental Arsenic Exposure on the Morphology of Multiple Organs in Female Mice During Pre‐Pregnancy, Gestation, and Lactation

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Cite This Study

Effects of Environmental Arsenic Exposure on the Morphology of Multiple Organs in Female Mice During Pre‐Pregnancy, Gestation, and Lactation

Discussion

Member takes

Implication

Key Points

Cite This Study

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