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June 27, 2026Indian Journal of Pharmacology

Morin ameliorates lipopolysaccharide-induced acute kidney injury in rats via alteration of TLR4/NF-κB, COX-2/PGE2, and monocyte chemoattractant protein-1/CXCL1 signaling pathway

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Authors

YWYuan WangQGQing GaoBHBo Hu

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Overview

Randomized trial demonstrates morin's protective effect on kidney function in rats, suggesting a therapeutic strategy for AKI.

Key Points

  • This study aims to investigate the protective effects of morin on acute kidney injury induced by lipopolysaccharide in rats.
  • Induced acute kidney injury using intraperitoneal LPS (10 mg/kg) in rats.
  • Administered morin orally at doses of 5, 10, and 15 mg/kg.
  • Measured various renal parameters, inflammatory cytokines, and mRNA expressions to assess kidney health.
  • Morin treatment improved body weight and reduced renal weight and renal index significantly.
  • Significant changes in renal parameters including creatinine and blood urea nitrogen were observed after morin administration.
  • Alterations in cytokine levels and expression of relevant signaling pathways were noted, indicating a protective mechanism of morin.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a3f68a3aea7db3c1953fa74https://doi.org/10.4103/ijp.ijp_975_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  3. 3Morin ameliorates myocardial injury in diabetic rats via modulation of inflammatory pathways2024 · 7 citations
  4. 4Ranolazine is associated with attenuation of lipopolysaccharide-induced acute kidney injury via modulation of inflammatory, oxidative, and vascular markers2026
  5. 5Renoprotective Effects of a Herbal Formulation Against Lipopolysaccharide-Induced Acute Kidney Injury Through Anti-Inflammatory and Antioxidant Activities2026