What is the clinical evidence from this study?

Study design: Other. Population: Sepsis-associated acute kidney injury (n=32). Intervention: Ranolazine vs. LPS alone. Primary outcome: Renal injury markers (inflammation, oxidative stress, apoptosis, and renal function).

What question did this study set out to answer?

This study aims to investigate the protective effects of ranolazine against lipopolysaccharide-induced acute kidney injury.

July 3, 2026Toxicology and Applied Pharmacology

Ranolazine is associated with attenuation of lipopolysaccharide-induced acute kidney injury via modulation of inflammatory, oxidative, and vascular markers

View Full Paper

Ask AI

Bookmark

Key result

Prophylactic ranolazine attenuates injury and preserves renal function in a rat model of sepsis-associated AKI.

n=32

Why the study?

Sepsis triggers acute kidney injury through inflammatory, oxidative, apoptotic, and microvascular mechanisms, prompting investigation into the renoprotective effects of ranolazine in a lipopolysaccharide-induced model.

Does ranolazine prevent lipopolysaccharide-induced acute kidney injury in a rat model?

Comparison

Control vs LPS vs LPS + ranolazine vs ranolazine

Design

Preclinical animal study

Authors

AAAtila AltuntaşSüleyman Demirel University ÖKÖznur KolaySüleyman Demirel University MTMuhammet Yusuf TepebasiSüleyman Demirel University

Discussion

Member takes

Implication

No immediate clinical role for ranolazine in sepsis-AKI; leaves open translation of renoprotection to human trials.

Key Points

This study aims to investigate the protective effects of ranolazine against lipopolysaccharide-induced acute kidney injury.
Thirty-two male Wistar albino rats were divided into four groups: Control, LPS, LPS + RAN, and RAN.
Ranolazine was administered orally at a dose of 100 mg/kg twice daily for three days after LPS induction.
Histopathological and immunohistochemical analyses were performed, along with biochemical assessments of kidney function and inflammatory markers.
LPS treatment caused significant renal injury with increased levels of TNF-α, Cas-3, and oxidative stress indicators (TOS, OSI, BUN, creatinine).
Ranolazine treatment significantly reduced inflammation and oxidative stress markers, preserving renal function and tubular transport signaling.
Prophylactic RAN partially restored vascular and hypoxia-related signaling pathways in sepsis-associated AKI.

Structured PICO

Does ranolazine prevent lipopolysaccharide-induced acute kidney injury in a rat model?

Population

32 male Wistar albino rats subjected to a lipopolysaccharide-induced acute kidney injury model.

Intervention

Ranolazine 100 mg/kg orally, twice daily for three days, followed by LPS 5 mg/kg intraperitoneal

Comparator

LPS alone (5 mg/kg, intraperitoneal), Control group, and Ranolazine alone group

Outcome

Renal injury assessed by histopathological and immunohistochemical analysis (NF-κB, TNF-α, Cas-3), biochemical markers (TAS, TOS, OSI, BUN, creatinine), and gene expression (IL-1β, SIRT-1, HO-1, HIF-1α, VEGF, eNOS, FLT-1, AQP-2, SCNN1A, NGAL, KIM1) at 6 hours post-LPSsurrogate

Prophylactic ranolazine attenuates inflammation, oxidative stress, and tubular injury in a rat model of sepsis-associated acute kidney injury.

Cite This Study

Altuntaş et al. (2026) studied Sepsis-associated acute kidney injury (n=32). Ranolazine vs. LPS alone was evaluated on Renal injury markers (inflammation, oxidative stress, apoptosis, and renal function). Prophylactic ranolazine attenuated inflammation, oxidative stress, and tubular injury while preserving renal function in a rat model of sepsis-associated acute kidney injury.

synapsesocial.com/papers/6a475a2e5c29257aa257ae4a https://doi.org/10.1016/j.taap.2026.117931

View Full Paper

Ask AI

Bookmark

Ranolazine is associated with attenuation of lipopolysaccharide-induced acute kidney injury via modulation of inflammatory, oxidative, and vascular markers

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Ranolazine is associated with attenuation of lipopolysaccharide-induced acute kidney injury via modulation of inflammatory, oxidative, and vascular markers

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider