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June 27, 2026Cell Death and DiseaseOpen Access

NINJ1 plays a vital role in the release of neutrophil extracellular traps during acute lung injury

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Authors

WZW. Z. ZhongLYLiu YXYX L Yang

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Overview

Randomized trial highlights the role of NINJ1 in NET release in neutrophils, suggesting it as a therapeutic target for acute lung injury.

Key Points

  • The study aims to explore the role of NINJ1 in neutrophil extracellular trap (NET) release during acute lung injury (ALI).
  • Utilized single-cell RNA sequencing and hotspot analysis to identify NINJ1 expression.
  • Investigated NINJ1 oligomerization's role in NET release in neutrophils from ARDS patients and ALI mice.
  • Performed genetic ablation of Ninj1 in neutrophils to assess its impact on NET release and pulmonary dysfunction.
  • NINJ1 was highly expressed in pro-inflammatory neutrophil subpopulations during ALI.
  • Genetic ablation of Ninj1 in neutrophils completely abolished NET release and reduced ALI-related lethality.
  • K45 and N60 were identified as critical residues for NINJ1 oligomerization and subsequent NET release.

Cite This Study

Zhong et al. (2026) studied this question.

synapsesocial.com/papers/6a3f68cdaea7db3c1953fcfbhttps://doi.org/10.1038/s41419-026-08995-5
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