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The aim is to explore the genetic characteristics and implications of primary breast follicular lymphoma without BCL2 rearrangement.

June 27, 2026Blood ResearchOpen Access

Primary breast follicular lymphoma without a BCL2 rearrangement: insights into extranodal lymphoma biology

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The aim is to explore the genetic characteristics and implications of primary breast follicular lymphoma without BCL2 rearrangement.
Case presentation of a 55-year-old woman with primary breast FL grade 3A.
Molecular characterization including immunohistochemistry and next-generation sequencing.
Staging via PET-CT to confirm localized disease.
Identified biallelic CREBBP mutations and a FOXO1 mutation.
No BCL2 rearrangements detected; instead, there were copy-number gains involving several oncogenes.
The disease was confined to the breast (stage IE), treated successfully with R-CHOP chemotherapy and radiotherapy.

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Case presentation of primary breast follicular lymphoma showing unique genetic characteristics, suggesting new pathways for diagnosis.

Seth et al. (2026) studied this question.

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