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June 27, 2026Pediatric Neurosurgery

Recurrent Pediatric Pilocytic Astrocytoma with BRAFV600E and TP53 Mutations: Case Report and Literature Review

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Authors

YMYazid MaghrabiSBSaleh BaeesaAAAlaa Alkhotani

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Overview

Case report demonstrates aggressive behavior of recurrent pilocytic astrocytoma with dual mutations, indicating increased risk for regrowth.

Key Points

  • This case aims to highlight the recurrence of pilocytic astrocytoma due to BRAFV600E and TP53 mutations.
  • Detailed review of a case involving a 10-year-old with recurrent pilocytic astrocytoma.
  • Analysis of genomic alterations associated with tumor behavior.
  • Literature review on the implications of BRAFV600E and TP53 mutations in pediatric astrocytomas.
  • The patient exhibited recurrent pilocytic astrocytoma with concurrent BRAFV600E and TP53 mutations.
  • The presence of these mutations was correlated with more aggressive tumor characteristics.
  • This case underscores the importance of analyzing specific molecular variants for assessing recurrence risk.

Cite This Study

Maghrabi et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6972aea7db3c195404c5https://doi.org/10.1159/000553295
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