Key result
Metabolic remodeling in heart failure may function similarly to oncometabolism in cancer, directly impacting cardiac cellular phenotype and pathogenesis beyond mere ATP production.
Why the study?
Despite decades of research, the precise relevance of metabolic remodeling in the pathogenesis of heart failure beyond ATP production has remained elusive.
This review proposes a novel paradigm where metabolic remodeling in heart failure directly impacts cellular phenotype and function, similar to oncometabolism in cancer.
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Metabolic remodeling's role in heart failure pathogenesis remains elusive; leaves open whether it represents a viable therapeutic target.
Kuhn et al. (2022) conducted a review in Heart failure. Metabolic remodeling (Oncometabolism) was evaluated. Metabolic remodeling in heart failure may function similarly to oncometabolism in cancer, directly impacting cardiac cellular phenotype and pathogenesis beyond mere ATP production.
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