Key result
Insulin, IGF-I, and dexamethasone increased the proportion of preadipocytes in rat stromal vascular cells, demonstrating that preadipocyte proliferation and early differentiation occur simultaneously.
Population
Freshly isolated stromal vascular (S-V) cells from rat inguinal adipose tissues
Comparison
Insulin, dexamethasone, insulin-like growth… vs Lower doses of insulin or non-insulin treated…
Design
Preclinical
Follow-up
2 days
Authors
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No immediate clinical implications for obesity; leaves open whether rat preadipocyte mechanisms translate to human adipose expansion.
Stromal vascular cells are recruited as preadipocytes, and the proliferation and early differentiation of these cells occur simultaneously and are enhanced by insulin, IGF-I, and dexamethasone.
Kras et al. (1999) studied Adipocyte development. Insulin, dexamethasone (DEX), and insulin-like growth factor-I (IGF-I) vs. 0, 0.1, or 1.0 nM insulin, or non-insulin treated cells was evaluated on Proportion and number of preadipocytes. Insulin, IGF-I, and dexamethasone increased the proportion of preadipocytes in rat stromal vascular cells, demonstrating that preadipocyte proliferation and early differentiation occur simultaneously.
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