Key result
Elevated systolic blood pressure (≥170 mm Hg) was associated with an increased relative risk of renal cell cancer in women (RR 2.0) compared to <130 mm Hg, whereas no association was observed in men.
Why the study?
Does elevated blood pressure increase the risk of incident renal cell cancer in adult men and women?
Population
72,416 adults from the Nord Trøndelag Health Study in Norway, without prevalent cancer and with complete…
Comparison
Elevated systolic blood pressure and diastolic… vs Systolic blood pressure <130 mm Hg and diastolic…
Design
Cohort
Follow-up
18 years
Authors
Loading...
Hypertension targets should remain unchanged; leaves open whether sex-specific renal cell cancer associations are causal or confounded.
Cohort (n=72,416)
Does elevated blood pressure increase the risk of incident renal cell cancer in adult men and women?
Relative Risk: 2 (95% CI 0.9–4.6)
p-value: p=0.11
Elevated systolic blood pressure is associated with an increased risk of incident renal cell cancer in women, but not in men, suggesting a potential sex-specific role of hypertension in renal carcinogenesis.
Vatten et al. (2007) conducted a cohort in Renal cell cancer (n=72,416). Elevated systolic blood pressure vs. Systolic blood pressure <130 mm Hg was evaluated on Incident renal cell cancer (RR 2.0, 95% CI 0.9-4.6, p=0.11). Elevated systolic blood pressure (≥170 mm Hg) was associated with an increased relative risk of renal cell cancer in women (RR 2.0) compared to <130 mm Hg, whereas no association was observed in men.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: