Why the study?
Does diuretic medication use increase the risk of renal cell carcinoma in health maintenance organization members?
Population
Health maintenance organization members in western Washington State, including 238 cases diagnosed with…
Comparison
Diuretic medication use and nondiuretic… vs Non-use of diuretic or nondiuretic…
Design
Case-control
Authors
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Hypertension likely confounds the diuretic-RCC link in women; leaves open independent effects and requires prospective confirmation.
Does diuretic medication use increase the risk of renal cell carcinoma in health maintenance organization members?
The apparent association between diuretic use and increased risk of renal cell carcinoma in women is likely confounded by hypertension, which itself is associated with increased RCC risk.
Shapiro et al. (1999) studied this question.
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