Key result
Lower FEV1 (OR 1.76) and reduced endothelial function (OR 1.30) were mutually independent predictors of atherosclerosis, and endothelial dysfunction did not mediate the association between airflow limitation and atherosclerosis.
Why the study?
Does systemic endothelial dysfunction mediate the association between reduced FEV1 and increased atherosclerosis?
Cross-Sectional (n=559)
No
Does systemic endothelial dysfunction mediate the association between reduced FEV1 and increased atherosclerosis?
Airflow limitation and endothelial dysfunction are independent, unrelated predictors of atherosclerosis, suggesting that endothelial dysfunction does not mediate the link between reduced lung function and cardiovascular disease.
Answers are grounded in this paper and cite their sources.
Does not support practice change; leaves open causal role of lung function in atherosclerosis.
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Chandra et al. (2016) conducted a cross-sectional in Atherosclerosis (n=559). Lower FEV1 vs. Higher FEV1 was evaluated on Carotid plaque (per 25% lower % predicted FEV1 in SCCOR cohort) (OR 1.76, 95% CI 1.30-2.40, p=<0.001). Lower FEV1 (OR 1.76) and reduced endothelial function (OR 1.30) were mutually independent predictors of atherosclerosis, and endothelial dysfunction did not mediate the association between airflow limitation and atherosclerosis.
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