What question did this study set out to answer?

To evaluate the echocardiographic and clinical outcomes after left bundle branch area pacing (LBBAP) and identify predictors of improvement.

June 27, 2026EP EuropaceOpen Access

Echocardiographic outcomes across different capture types in left bundle branch area pacing: a real-world cohort analysis

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Why the study?

Does the capture type in left bundle branch area pacing affect echocardiographic response and clinical outcomes in paced patients?

Population

655 patients receiving LBBAP

Comparison

Confirmed vs probable vs left septal vs deep septal capture

Design

Prospective cohort analysis

Authors

DMD MartinezHospitais da Universidade de Coimbra MPM J PrimoHospitais da Universidade de Coimbra ICI CruzHospitais da Universidade de Coimbra

Discussion

Member takes

Implication

Observed LVEF gains in this cohort should not change practice; leaves open need for randomized outcome trials.

Key Points

To evaluate the echocardiographic and clinical outcomes after left bundle branch area pacing (LBBAP) and identify predictors of improvement.
Prospective analysis of 655 patients receiving LBBAP.
Echocardiography assessed left ventricular ejection fraction (LVEF) at baseline and follow-up to calculate ΔLVEF.
Logistic regression and Cox proportional hazards models analyzed predictors of echocardiographic responses and clinical outcomes.
Baseline LVEF increased from 50.2% to 52.7% (p < 0.001), with 4.1% showing significant improvement.
Capture was confirmed in 75.8%, with low clinical event rates: mortality 6.6%, HF hospitalization 1.7%, and composite endpoint 8.4%.
Age was an independent predictor of composite events (HR 1.07 per year, p = 0.04), while capture category was not significant after adjustment.

Structured PICO

Does the capture type in left bundle branch area pacing affect echocardiographic response and clinical outcomes in paced patients?

Population

655 patients receiving left bundle branch area pacing (LBBAP), median age 75, 67.5% male.

Intervention

Left bundle branch area pacing (LBBAP)

Outcome

Change in left ventricular ejection fraction (ΔLVEF) and echocardiographic response (ΔLVEF > 10%)surrogate

LBBAP results in modest but consistent improvement in systolic function, with the greatest benefit seen in patients with confirmed or probable capture.

Cite This Study

Martinez et al. (2026) studied this question.

synapsesocial.com/papers/6a3f9785125782b61d8657eb https://doi.org/10.1093/europace/euag105.705

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Echocardiographic outcomes across different capture types in left bundle branch area pacing: a real-world cohort analysis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Echocardiographic outcomes across different capture types in left bundle branch area pacing: a real-world cohort analysis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider