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June 27, 2026EP EuropaceOpen Access

Catheter ablation for sustained VT in HCM shows a ~44% recurrence rate.

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Why the study?

Data on catheter ablation for VT in HCM remain limited, with prior studies mainly addressing feasibility and safety rather than long-term efficacy or arrhythmogenic substrate characteristics.

Does catheter ablation provide long-term arrhythmia control in patients with hypertrophic cardiomyopathy and sustained ventricular tachycardia?

Population

16 patients with HCM undergoing catheter ablation for sustained VT

Comparison

Combined endocardial/epicardial ablation vs endocardial-only ablation

Design

Retrospective single-center study

Follow-up

Mean 49.6 ± 32.9 months (median 53.4, IQR 18.3–84.6)

Key result

Catheter ablation for sustained ventricular tachycardia in patients with hypertrophic cardiomyopathy resulted in a 43.8% VT recurrence rate and a median VT-free survival of 73.5 months.

Authors

AKA KeresteciCCC CoteliHYH Yorgun

Discussion

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Member takes

Overview

May support durable VT control in select cases; hypothesis-generating and should not yet change practice.

Key Points

  • Evaluate the clinical characteristics and long-term outcomes of catheter ablation for sustained ventricular tachycardia in hypertrophic cardiomyopathy.
  • Retrospective single-center study of 16 patients with hypertrophic cardiomyopathy who underwent catheter ablation.
  • Data on clinical, echocardiographic, and procedural outcomes were collected from electronic medical records.
  • Mean follow-up duration of 49.6 ± 32.9 months to assess long-term outcomes.
  • 43.8% of patients experienced VT recurrence during follow-up.
  • Median VT-free survival time was 73.5 months (95% CI 33.9–113.0).
  • No major procedural complications were observed.

Study Design

Type

Observational (n=16)

Multicenter

No

Structured PICO

Does catheter ablation provide long-term arrhythmia control in patients with hypertrophic cardiomyopathy and sustained ventricular tachycardia?

P
Population
16 patients with hypertrophic cardiomyopathy who underwent catheter ablation for sustained ventricular tachycardia, followed for a mean of 49.6 months.
E
Exposure
Catheter ablation for sustained ventricular tachycardia (combined endocardial and epicardial mapping/ablation in 56%, endocardial-only ablation in 44%)
O
Outcome
Ventricular tachycardia (VT) recurrence and VT-free survival timehard clinical

Catheter ablation for sustained ventricular tachycardia in patients with hypertrophic cardiomyopathy is feasible, safe, and provides acceptable long-term arrhythmia control with a median VT-free survival of 73.5 months.

Cite This Study

Keresteci et al. (2026) conducted an observational in Hypertrophic cardiomyopathy with sustained ventricular tachycardia (n=16). Catheter ablation was evaluated on Ventricular tachycardia recurrence. Catheter ablation for sustained ventricular tachycardia in patients with hypertrophic cardiomyopathy resulted in a 43.8% VT recurrence rate and a median VT-free survival of 73.5 months.

synapsesocial.com/papers/6a3f97bb125782b61d865978https://doi.org/10.1093/europace/euag105.1101
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Radiofrequency catheter ablation of ventricular arrhythmias in patients with hypertrophic cardiomyopathy2023 · 2 citations
  2. 2Clinical outcomes of radiofrequency catheter ablation of ventricular tachycardia in patients with hypertrophic cardiomyopathy2022 · 18 citations
  3. 3Catheter ablation versus antiarrhythmic drug therapy for sustained ventricular tachycardia in patients with hypertrophic cardiomyopathy2024 · 2 citations
  4. 4Impact of phenotypic profile and genotype on ventricular tachycardia ablation outcomes in hypertrophic cardiomyopathy2026
  5. 5Long-Term Outcomes of Combined Epicardial and Endocardial Ablation of Monomorphic Ventricular Tachycardia Related to Hypertrophic Cardiomyopathy2011 · 157 citations