Key result
Higher accelerometer-measured moderate-to-vigorous physical activity was associated with lower all-cause mortality (HR 0.93 per 10 min/day; 95% CI 0.89-0.98) among myocardial infarction survivors.
Why the study?
The study was conducted to examine dose-response associations of accelerometer-measured moderate-to-vigorous physical activity, light-intensity physical activity, and sedentary time with all-cause and ischemic heart disease mortality among myocardial infarction survivors.
Does higher accelerometer-measured physical activity reduce all-cause and IHD mortality in myocardial infarction survivors?
Cohort (n=2,108)
Does higher accelerometer-measured physical activity reduce all-cause and IHD mortality in myocardial infarction survivors?
Higher accelerometer-measured moderate-to-vigorous physical activity is associated with a dose-dependent reduction in all-cause and ischemic heart disease mortality among MI survivors.
Objectives: To examine dose–response associations of accelerometer-measured moderate-to-vigorous physical activity (MVPA), light-intensity physical activity (LIPA), and sedentary time (ST) with all-cause and ischemic heart disease (IHD) mortality among myocardial infarction (MI) survivors. Methods: UK Biobank participants with a confirmed history of MI were included. Wrist-worn accelerometers quantified daily MVPA, LIPA, and ST. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for each exposure (single-exposure models) and mutually adjusted partition models that included MVPA, LIPA, and ST simultaneously. Dose effects were modeled per 10 min/day higher MVPA and per 1 h/day higher LIPA and ST, and MVPA was also analyzed in five categories (0-<15, 15-<30, 30-<45, 45-<60, ≥60 min/day). Restricted cubic splines were used to visualize dose–response patterns. Results: A total of 2,108 MI survivors were included (mean age 67.51 years; 79.13% men). During a median follow-up of 7.8 years (IQR 7.3–8.4) and over 15,920.63 person-years, 295 all-cause deaths and 74 IHD deaths occurred. In partition models, higher MVPA was associated with lower all-cause mortality (per 10 min/day: HR 0.93, 95% CI 0.89–0.98) and lower IHD mortality (per 10 min/day: HR 0.88, 95% CI 0.80–0.98). Compared with MVPA 0–<15 min/day, MVPA ≥60 min/day was associated with lower all-cause mortality (HR 0.50, 95% CI 0.33–0.76) and lower IHD mortality (HR 0.40, 95% CI 0.17–0.92). Higher LIPA was inversely associated with all-cause mortality (per 1 h/day: HR 0.85, 95% CI 0.77–0.93), but not with IHD mortality (HR 1.03, 95% CI 0.85–1.24). ST was not independently associated with all-cause mortality (per 1 h/day: HR 0.97, 95% CI 0.90–1.04), or IHD mortality (HR 1.03, 95% CI 0.85–1.24). Conclusions: Among MI survivors, higher accelerometer-measured MVPA was consistently associated with lower all-cause and IHD mortality. LIPA showed an inverse association with all-cause mortality, while ST was not independently associated with mortality in mutually adjusted models.
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Liu et al. (2026) conducted a cohort in myocardial infarction (n=2,108). Moderate-to-vigorous physical activity (MVPA) vs. Lower levels of MVPA was evaluated on all-cause mortality (HR 0.93, 95% CI 0.89-0.98). Higher accelerometer-measured moderate-to-vigorous physical activity was associated with lower all-cause mortality (HR 0.93 per 10 min/day; 95% CI 0.89-0.98) among myocardial infarction survivors.
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